| 1 | Fisetin | Fabaceae | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | Eudicotyledons | Central/ East Africa | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087220/ |
| 2 | Baicalein | NA | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | NA | Central / East Africa | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 3 | Epigallocatechin gallate (EGGC) | NA | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | NA | Central/ East Africa | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 4 | Naringenin | NA | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | NA | Central/ East Africa | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 5 | Silymarin | NA | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | NA | Central/ East Africa | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 6 | Tomatidine | Spirosolanes and Derivatives | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | Europe | Central/ East Africa | Epidemic | 32286447 | 10.1038/s41598-020-63397-7 | NA | unripe tomato | alkaloids |
| 7 | Decanoylphorbol-13 acetate | Diterpene | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | NA | Central/ East Africa | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Croton mauritianus (leaves) | NA |
| 8 | *Compound 3 (Jatrophane esters) | NA | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | NA | Central/ East Africa | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Euphorbia amygdaloides spp.and semiperfoliata
(Whole plant) | NA |
| 9 | Curcumin | Ginger Family , Zingiberaceae | CHIKV | Chikungunya virus | Alphavirus | Togaviridae | RNA | NA | High fever ,Joint pain ,Joint swelling ,Rash ,Headache ,Muscle pain ,Nausea ,Fatigue | south western tropical Asia region | Central/East Africa | Epidemic | 28343845 | 10.1016/j.antiviral.2017.03.014 | NA | NA | NA |