| 1 | Bupleurum sp. | Apiaceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | China | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 2 | Oenanthe javanica | Apiaceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Asia | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 3 | Saussurea lappa | Asteraceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Tibbat, China | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 4 | Terminalia chebula | Combretaceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Nepal,srilanka,india,china | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 5 | Pericampylus glaucus | Menispermaceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Malaysia, India, China | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 6 | Picrorhiza kurroa | Plantaginaceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Nepal | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 7 | Ranunculus scleratus | Ranunculaceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | North America | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 8 | Agrimonia eupatoria | Rosaceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | East Europe | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 9 | Rubia cardifolia | Rubiaceae | HBV | Hepatitis B virus | | Hepadnavirus | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | India | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 10 | Glycyrrhiza glabra | Fabaceae | HBV | Hepatitis B virus | | | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Eurasia | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 11 | Potentila anserine | Rosaceae | HBV | Hepatitis B virus | | | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | California, America | Central Asia, Middle east | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 12 | Phyllanthus amarus | Phyllanthaceae | HBV | Hepatitis B virus | | | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | India | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 13 | Phyllanthus urinaria | Phyllanthaceae | HBV | Hepatitis B virus | | | DNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | West indies | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 14 | Ophioglossum pedunculosum Desv. | Ophioglossaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Kermadecs, New Zealand | NA | NA | PMC7120890 | 10.1007/978-94-007-3926-0_3 | NA | NA | NA |
| 15 | Polygonum cuspidatum Sieb. and Zucc. | Polygonaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Japan, Taiwan, Korea, and Eastern China. | NA | NA | PMC7120890 | 10.1007/978-94-007-3926-0_3 | NA | NA | NA |
| 16 | Boehmeria nivea L. | Urticaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Malaysia | NA | NA | PMC7120890 | 10.1007/978-94-007-3926-0_3 | NA | NA | NA |
| 17 | Epigallocatechin gallate (EGGC) | NA | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | NA | NA | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 18 | Ranunculus sieboldii, Ranunculus sceleratus | Apigenin 4′-O-α-rhamnopyranoside, apigenin 7-O-β-glucopyranosyl-4′-O-α-rhamnopyranoside, tricin 7-O-β-glucopyranoside, tricin, isoscopoletin | HBV | Hepatitis B | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | North America | NA | Epidemic | 23153834 | 10.1016/j.antiviral.2012.10.006 | NA | TCHM-derived compounds inhibiting viral replication. | NA |
| 19 | Radix sophorae Flavescentis | Oxymatrine | HBV | Hepatitis B | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | China and japan | NA | Epidemic | 23153834 | 10.1016/j.antiviral.2012.10.006 | NA | TCHM-derived compounds inhibiting viral replication. | NA |
| 20 | Salvia miltiorrhiza | Protocatechuic aldehyde | HBV | Hepatitis B | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | China | NA | NA | 23153834 | 10.1016/j.antiviral.2012.10.006 | NA | TCHM-derived compounds inhibiting viral replication. | NA |
| 21 | Radix bupleuri | Saikosaponin C | HBV | Hepatitis B | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Hafizabad district, Punjab-Pakistan | NA | Epidemic | 23153834 | 10.1016/j.antiviral.2012.10.006 | NA | TCHM-derived compounds inhibiting viral replication. | NA |
| 22 | Radix scutellariae | Wogonin | HBV | Hepatitis B | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Japan | NA | NA | 23153834 | 10.1016/j.antiviral.2012.10.006 | NA | TCHM-derived compounds inhibiting viral replication. | NA |
| 23 | Swerilactones | Lactones | HBV | Hepatitis B | NA | Hepadnavirus | DNA | NA | NA | NA | NA | NA | NA | 10.4172/2168-9652.1000220 | NA | Swertia mileensis (whole plant) | NA |
| 24 | LPRP-Et-97543 | NA | HBV | Hepatitis B | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | NA | NA | NA | 10.4172/2168-9652.1000220 | NA | Liriope platyphylla
(Root) | NA |
| 25 | Laggera alata | Asteraceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Africa and Asia | NA | NA | 24872930 | 10.4103/2225-4110.124335 | NA | sochlorogenic acid A from Laggera alata | NA |
| 26 | Curcumin | Ginger Family , Zingiberaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | south western tropical Asia region | NA | NA | 24872930 | 10.4103/2225-4110.124335 | NA | Viral transcription suppressor via down‑regulation of the coactivator PGC‑1α | NA |
| 27 | Corydalis saxicola | Papaveraceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | temperate Northern Hemisphere | NA | NA | 24872930 | 10.4103/2225-4110.124335 | NA | Dehydrocheilanthifoline isolated from Corydalis saxico | NA |
| 28 | Piper longum | Piperaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Java, Indonesia | NA | NA | 24872930 | 10.4103/2225-4110.124335 | NA | Amide alkaloid from Piper longum | NA |
| 29 | Polygonum cuspidatum | Polygonaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | East Asia in Japan, China and Korea | NA | NA | 24872930 | 10.4103/2225-4110.124335 | NA | Ethanol extract from Polygonum cuspidatum | NA |
| 30 | Saikosaponins | Umbelliferae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Eurasia | NA | NA | 24872930 | 10.4103/2225-4110.124335 | NA | aikosaponins (C, D) from Bupleurum species | NA |
| 31 | Ocimum basilium | lamiaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | india | Middle East & North Africa | Epidemic | NA | 10.7897/2230-8407.04603 | NA | NA | NA |
| 32 | Polygonum cuspidatum | polygonaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | East Asia in Japan, China and Korea | Middle East & North Africa | Epidemic | NA | 10.7897/2230-8407.04603 | NA | NA | NA |
| 33 | Picrorhiza kurroa | Scrophulariaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Himalayan regions of China, Pakistan, India, | Middle East & North Africa | Epidemic | NA | 10.7897/2230-8407.04603 | NA | NA | NA |
| 34 | Boehmeria nivea | Urticaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | China | Middle East & North Africa | Epidemic | NA | 10.7897/2230-8407.04603 | NA | NA | NA |
| 35 | Polygonum cuspidatum Sieb. & Zucc. | Polygonaceae – Buckwheat | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Europe and temperate Asia | NA | Epidemic | 17981353 | 10.1016/j.virusres.2007.09.008 | NA | NA | NA |
| 36 | Boehmeria nivea L. | Urticaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Europe and temperate Asia | NA | Epidemic | 17981353 | 10.1016/j.virusres.2007.09.008 | NA | NA | NA |
| 37 | Boehmeria nivea L. | Urticaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Malaysia | NA | NA | 17981353 | 10.1016/j.virusres.2007.09.008 | NA | Huang et al. (2006) | NA |
| 38 | Polygonum cuspidatum Sieb. & Zucc. | Polygonaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | mountainous regions of Japan, Taiwan, Korea, and Eastern China | NA | NA | 17981353 | 10.1016/j.virusres.2007.09.008 | NA | Chang et al. (2005) | Inhibits hepatitis B virus in a stable HBV-producing cell line |
| 39 | Ocimum basilicum | Lamiaceae | HBV | Hepatitis B virus | NA | Hepadnavirus | DNA | NA | NA | North Africa, southern and southeastern Europ | NA | NA | 29258916 | 10.1016/j.phrs.2017.12.016 | NA | NA | NA |