| 1 | Wrightia tinctoria | Apocynaceae | HCV | Hepatitis C Virus | | | RNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | India | Africa, East Asia | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 2 | Alpinea galanga | Zingiberaceae | HCV | Hepatitis C Virus | | | RNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Indonesia | Africa, East Asia | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 3 | Zingiber officinale | Zingiberaceae | HCV | Hepatitis C Virus | | | RNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | South east asia | Africa, East Asia | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 4 | Glycyrrhiza glabra | Fabaceae | HCV | Hepatitis C Virus | | | RNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Eurasia | Middle East & North Africa | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 5 | Hypericum perforatum | Hypericaceae | HCV | Hepatitis C virus | | | RNA | | Abdominal pain, dark urine, fever,joint pain,vomiting | Europe | Africa, East Asia | Epidemic | | 10.1007/s40011-011-0016-7 | | | |
| 6 | Acacia nilotica L. | Fabaceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Africa | Africa, East Asia | Epidemic | PMC7120890 | 10.1007/978-94-007-3926-0_3 | NA | NA | NA |
| 7 | Solanum nigrum L. | Solanaceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Eurasia and introduced in the Americas, | Africa, East Asia | Epidemic | PMC7120890 | 10.1007/978-94-007-3926-0_3 | NA | NA | NA |
| 8 | Resveratrol | natural compound | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Europe | Africa , East Asia | epidemic | 26693226 | 10.1155/2015/184241 | NA | naturally occurring polyphenol stilbene found mostly in fermented grapes, mulberry, red wine, and peanuts | An antioxidant resveratrol significantly enhanced replication of hepatitis C virus |
| 9 | Naringenin | NA | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 10 | Quercetin | NA | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | Embelia ribes (seeds) |
| 11 | Silibinin | NA | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 12 | Silymarin | NA | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 13 | Apigenin chemical found in vegetables and fruits | NA | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 14 | Licorice (Component - GL) | Fabaceae | HCV | Hepatitis C | NA | NA | RNA | NA | NA | China, India | NA | NA | 25838832 | 10.1155/2015/642327 | NA | Root of licorice | NA |
| 15 | Eclipta Alba | Asteraceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Bangladesh | Africa, East Asia | Epidemic | 26870673 | 10.1016/j.jtcme.2015.09.005 | NA | NA | NA |
| 16 | Rhodiola kirilowii | 3,3′-Digalloylproprodelphinidin B2, 3,3′-Digalloylprocyanidin B2, (−)-Epigallocatechin-3-O-gallate, (−)-Epicatechin-3-O-gallate | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | East Asia | Africa, East Asia | Epidemic | 23153834 | 10.1016/j.antiviral.2012.10.006 | NA | TCHM-derived compounds inhibiting viral replication. | NA |
| 17 | Saxifraga melanocentra | Polyphenolic compounds | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | China and Indian | Africa, East Asia | Epidemic | 23153834 | 10.1016/j.antiviral.2012.10.006 | NA | TCHM-derived compounds inhibiting viral replication. | NA |
| 18 | Limonoids | Lignin | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Swietenia macrophylla (stem) | NA |
| 19 | Excoecarianin | Phyllanthaceae | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | tropical Asia | Africa, East Asia | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Phyllanthus urinaria (whole plant) | NA |
| 20 | Loliolide | Tannins | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Phyllanthus urinaria (whole plant) | NA |
| 21 | Saikosaponins | Terpenoid | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Bupleurum kaoi (roots) | NA |
| 22 | Saikosaponin b2 (Terpenoid) | NA | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Bupleurum kaoi (Root) | NA |
| 23 | Chalepin and pseudane IX | NA | HCV | Hepatitis C | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Ruta angustifolia (Leaves) | NA |
| 24 | Silybum marianum | Asteraceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Southern Europe | Africa, East Asia | Epidemic | 24872930 | 10.4103/2225-4110.124335 | NA | Standardized extracts of Silybum marianum | NA |
| 25 | Silybum marianum | Asteraceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Mediterranean regions of Europe | Africa, East Asia | Epidemic | 24872930 | 10.4103/2225-4110.124335 | NA | Flavonolignans from Silybum marianum | NA |
| 26 | Terminalia chebula | Combretaceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | South Asia from India and Nepal east to southwest China (Yunnan), and south to Sri Lanka, Malaysia, and Vietnam. | Africa, East Asia | Epidemic | 24872930 | 10.4103/2225-4110.124335 | NA | Tellimagrandin I from Rosae Rugosae Flos. HCV invasion inhibitor Chebulagic acid and punicalagin isolated from Terminalia chebula Retz. | NA |
| 27 | Curcumin | Ginger Family , Zingiberaceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | SOUTH WESTERN REGION | Africa, East Asia | Epidemic | 24872930 | 10.4103/2225-4110.124335 | NA | NA | NA |
| 28 | Ladanein | Lamiaceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | forest region | Africa, East Asia | Epidemic | 24872930 | 10.4103/2225-4110.124335 | NA | natural product | NA |
| 29 | Griffithsin( is a protien) | NA | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | 24872930 | 10.4103/2225-4110.124335 | NA | natural product | NA |
| 30 | epigallocatechin-3-gallate (acid) | NA | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | NA | Africa, East Asia | Epidemic | 24872930 | 10.4103/2225-4110.124335 | NA | Green tea catechins | https://www.ncbi.nlm.nih.gov/pubmed/21837753 |
| 31 | Saxifraga melanocentra(x) | lamiaceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | NA | Temperate region | Africa , East asia | Pandemic | NA | 10.7897/2230-8407.04603 | NA | NA | NA |
| 32 | Eclipta alba | Asteraceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | fever, fatigue, decreased appetite, nausea, vomiting, abdominal pain, dark urine, grey-coloured faeces, joint pain and jaundice | India, china, nepal,thailand, Brazil | Africa & Southeast Asia | Pandemic | 23026306 | 10.1016/j.jep.2012.09.036 | NA | NA | NA |
| 33 | Saxifraga melanocentra Engl. & Irmsch. | Saxifragaceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Malaysia | Africa, East Asia | Epidemic | 17981353 | 10.1016/j.virusres.2007.09.008 | NA | NA | NA |
| 34 | Saxifraga melanocentra Engl. & Irmsch. | Saxifragaceae | HCV | Hepatitis C Virus | NA | NA | RNA | NA | Abdominal pain, dark urine, fever,joint pain,vomiting | Temperate region | Africa, East Asia | Epidemic | 17981353 | 10.1016/j.virusres.2007.09.008 | NA | Zuo et al. (2005) | A compound namely 1,2,3,4,6-penta-O-galloyl-beta-d-glucoside isolated from Saxifraga melanocentra |