| 1 | pimpinella anisum | Illiciaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Europe and parts of western Asia, | East Africa | Epidemic | 21389629 | 10.1271/bbb.100645 | NA | Fruit | NA |
| 2 | Cissus quadrangularis | vitaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Asia, Arabia and much of Africa | East Africa | Epdiemic | 25206252 | NA | NA | NA | NA |
| 3 | Quercetin | NA | HSV-2 | NA | Simplexvirus | Herpesviridae | DNA | NA | NA | NA | NA | NA | NA | 10.3390/v12020184 | NA | flavonoid | NA |
| 4 | Artemisia arborescens | Asteraceae | HSV-2 | Herpes simplex virus type 2 | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Mediterranean region | East Africa | Epidemic | 28090211 | 10.1155/2016/3012462 | NA | Aerial parts | β-Thujone, linalool, myrcene, carvacrol |
| 5 | Melissa officinalis | Lamiaceae | HSV-2 | NA | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | southern and western Europe | East Africa | Epidemic | 28090211 | 10.1155/2016/3012462 | NA | Leaves | Myrcene, linalool, camphor, citronellal, β-caryophyllene, caryophyllene oxide, citral |
| 6 | Hibiscus sabdariffa L. | Malvaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | India to Malaysia | East Africa | Epidemic | 25838832 | 10.1155/2015/642327 | NA | NA | NA |
| 7 | Spiroketalenol | Ether | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | NA | NA | East Africa | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Tanacetum vulgare (rhizome) | NA |
| 8 | Spiroketalenol ether derivative | NA | HSV-2 | Herpes simplex virus type-2 | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | NA | East Africa | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Tanacetum vulgare (Rhizome) | NA |
| 9 | Oxyresveratrol | NA | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | NA | East Africa | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Artocarpus lakoocha
(Heartwood) | NA |
| 10 | Lignin–carbohydrate complex (PPS-2b) | NA | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | NA | East Africa | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Prunella vulgaris
(Fruit spikes) | NA |
| 11 | Pterocarnin A | NA | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | NA | East Africa | Epidemic | NA | 10.4172/2168-9652.1000220 | NA | Pterocarya stenoptera (Bark) | NA |
| 12 | Cassia javanica | Fabaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Southeast Asia | East Africa | Epidemic | 24872930 | 10.4103/2225-4110.124335 | NA | nt‑Epiafzelechin‑(4α→8)‑epiafzelechin isolated from Cassia javanica against HSV‑2 | NA |
| 13 | Withania somnifera | Solanaceae | HSV-2 | Human simplex virus type-2 | Simplexvirus | Herpesviridae | double-stranded, linear DNA | NA | NA | Africa. southern Europe and western Asia | NA | NA | NA | 10.7897/2230-8407.04603 | NA | NA | NA |
| 14 | cranberry extract | Ericaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Asia | East Africa | Epidemic | NA | 10.1016/j.antiviral.2016.06.007 | NA | NA | NA |
| 15 | Phyllanthus urinaria L. | Phyllanthaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | tropical regions of Africa, Southern Asia, Australia, and various islands of the Indian Ocean | East Africa | Epidemic | 17981353 | 10.1016/j.virusres.2007.09.008 | NA | NA | NA |
| 16 | Santolina insularis | Asteraceae | HSV-2 | NA | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | eastern and south-central United States. | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | Full Blossom | NA |
| 17 | Matricaria chamomilla | Asteraceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | northeast Vietnam and southwest China | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | Flower | NA |
| 18 | Pongamia pinnata | Fabaceae | HSV-2 | NA | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Southeast Asia | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | seed | NA |
| 19 | Thymus vulgaris | Lamiaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Southern Europe | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | Leaf & Flower | NA |
| 20 | Hyssopus officinalis | Lamiaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | northern Mediterranean Basin, | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | Leaf & Flower | NA |
| 21 | Coptidis rhizoma | Ranunculaceae | HSV-2 | NA | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Nicaragua to S. Tropical America and Trinidad-Tobago. | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | whole plant | NA |
| 22 | Santalum album | Santalaceae | HSV-2 | NA | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Asia. | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | Commercially obtained | NA |
| 23 | Illicium verum | Schisandraceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Southern Europe | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | seed | NA |
| 24 | Zingiber officinale | Zingiberaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | Southern Europe, the Middle East, | East Africa | Epidemic | NA | 10.1016/B978-0-12-398539-2.00017-3 | NA | Root | NA |
| 25 | Shilajit | Euphorbiaceae | HSV-2 | Herpes Simplex Virus-2. | Simplexvirus | Herpesviridae | DNA | NA | Fever, Swollen lymph nodes, headaches, tiredness, lack of appetite | India & Tibbet | East Africa | epidemic | 25792012 | 10.1016/j.jep.2015.03.019 | NA | NA | NA |